Beatrice N Kiage-Mokua1,2,
Michael de Vrese1 
,
Ina Kraus-Stojanowic1,
Annegret Nielsen1,
Patrick Kareru2,
Gaston Kenji2,
Christine Onyango2,
Nils Roos1,
Darab Ghadimi1,
Jürgen Schrezenmeir1,3
For correspondence:- Michael de Vrese Email: darab.ghadimi@mri.bund.de Tel:+494316092512
Accepted: 19 September 2020 Published: 30 October 2020
Citation: Kiage-Mokua BN, de Vrese M, Kraus-Stojanowic I, Nielsen A, Kareru P, Kenji G, et al. Effect of extracts from selected Kenyan plants on traits of metabolic syndrome in Wistar rats fed a high-fat high-fructose diet. Trop J Pharm Res 2020; 19(10):2137-2146 doi: 10.4314/tjpr.v19i10.18
© 2020 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..
Purpose: To examine the potential of extracts from selected herbs used in African traditional medicine in diabetes patients, and to determine their effect on traits of metabolic syndrome in rats fed a high-fat and high-fructose diet.
Methods: Ethanol and aqueous extracts were prepared from Mangifera indica (MI), Lonchocarpus eriocalyx (LE), Urtica massaica (UM), Schkuhria pinnata (SP) and Launaea cornuta (LC). Ethanol extracts (1:100 dilution) were examined for inhibition of pancreatic lipase and α-glucosidase activity in vitro. Furthermore, aqueous extracts were administered for 74 days to male Wistar rats fed a high-fat and high-fructose diet to assess their effect on traits of metabolic syndrome.
Results: Ethanol extracts showed at least 30 % inhibition of pancreatic lipase in vitro but no effect on α-glucosidase activity. Administration of the aqueous extracts caused significant reduction in liver triglycerides (except for LE). Muscle triglycerides and fat were also reduced, with the most pronounced effect elicited by LE. Urinary glucose excretion and plasma triglycerides, but not hyperinsulinemia and insulin resistance, were reduced by UM compared to control.
Conclusion: This exploratory study indicates that UM may be considered a candidate for the prevention and management of type 2 diabetes.
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